ADAMTS3

Across TCGA patient cohorts, ADAMTS3 mutation is significantly associated with the RNA expression of many other genes, with 4,881 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS3-associated genes across cancer lineages are NUP58, GGNBP2, and PSMA3. Each is linked with ADAMTS3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAMTS3-to-partner and partner-to-ADAMTS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUP58 grouped by ADAMTS3-low versus ADAMTS3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS3→partner) and Y-score (partner→ADAMTS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NUP58 →	+0.472	+3.195	.008	.009	3	5
UCEC	GGNBP2 →	+0.273	+1.601	.002	.002	3	4
UCEC	PSMA3 →	+0.269	+1.524	.002	.006	3	4
UCEC	CLIP3 →	-0.449	-1.429	.005	<.001	3	4
UCEC	BCCIP →	+0.285	+1.696	.002	.001	3	4
STAD	ZNF330 →	+0.401	+3.334	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,881 associations by consensus.

NUP58 by ADAMTS3 expression — STAD

Explore this box plot interactively →