ADAMTS3

Across TCGA pan-cancer cohorts, ADAMTS3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ADAMTS3 data layer compared with 15 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ADAMTS3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADAMTS3 expression acts as an unfavorable survival marker, although some lineages such as LAML and HNSC show a favorable association.

BLCA, KIRP, and STAD are the cancer types where ADAMTS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.530	0.689	<.001	102	view →
KIRP	OS	Median	II,III,IV	0.712	0.916	.003	73	view →
STAD	OS	Tertile	All	0.498	0.678	.004	59	view →
MESO	DFS	Quartile	II,III,IV	0.227	0.506	.002	53	view →
LGG	OS	Median	All	0.362	0.525	<.001	42	view →
LAML	DFS	Median	All	0.536	0.205	<.001	42	view →
CESC	DFS	Tertile	All	0.393	0.705	.005	34	view →
HNSC	OS	Tertile	IV	0.562	0.352	.012	21	view →
BRCA	DFS	Median	IV	0.335	0.752	.001	19	view →
UVM	DFS	Median	III,IV	0.211	0.884	.002	18	view →
LUSC	OS	Tertile	III,IV	0.513	0.814	.010	16	view →
ACC	DFS	Median	All	0.590	0.855	.012	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ADAMTS3–BLCA (OS)

Open the BLCA breakdown →