ADAMTS3

Across TCGA patient cohorts, ADAMTS3 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS3-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and Caveolin-1. Each is linked with ADAMTS3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTS3-to-partner and partner-to-ADAMTS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ADAMTS3-low versus ADAMTS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS3→partner) and Y-score (partner→ADAMTS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.304	+3.169	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.595	+2.662	<.001	<.001	3	4
SKCM	Caveolin-1 →	-0.818	-2.321	.005	.033	3	3
UCEC	C-Raf →	+0.125	+1.206	.001	.009	3	3
STAD	ACVRL1 →	-0.195	-3.321	.026	.009	3	2
UCEC	P-Cadherin →	-0.134	-2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

4E-BP1 by ADAMTS3 expression — UCEC

Explore this box plot interactively →