ADAMTS3

Across TCGA cell cohorts, ADAMTS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,308 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAMTS3-associated GO terms across cancer lineages are Protein localization to nucleus, Electron transport chain, and Proton motive force-driven mitochondrial ATP synthesis. Each is linked with ADAMTS3 in more than 11 cancer types. Because this analysis shows association rather than direction, both ADAMTS3-to-partner and partner-to-ADAMTS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to nucleus grouped by ADAMTS3-low versus ADAMTS3-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS3→partner) and Y-score (partner→ADAMTS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Protein localization to nucleus →	+0.059	+1.222	<.001	<.001	3	12
PANCREAS	Electron transport chain →	+0.060	+0.429	.005	.003	3	11
PANCREAS	Proton motive force-driven mitochondrial ATP synthesis →	+0.077	+0.550	.002	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.100	+0.883	<.001	<.001	3	11
SKIN	Nucleoside triphosphate biosynthetic process →	+0.080	+1.016	.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Nucleocytoplasmic transport →	+0.100	+0.884	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,308 associations by consensus.

Protein localization to nucleus by ADAMTS3 expression — OVARY

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