ADAMTS3

Across TCGA cell cohorts, ADAMTS3 mutation is significantly associated with the RNA expression of many other genes, with 1,040 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS3-associated genes across cancer lineages are WDR87, RAB3A, and TBC1D30. Each is linked with ADAMTS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMTS3-to-partner and partner-to-ADAMTS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR87 grouped by ADAMTS3-low versus ADAMTS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS3→partner) and Y-score (partner→ADAMTS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR87 →	+0.013	+2.353	.001	.001	3	3
LARGE_INTESTINE	RAB3A →	+0.894	+3.169	<.001	.006	3	2
LARGE_INTESTINE	TBC1D30 →	+0.819	+2.043	.003	.008	3	2
LARGE_INTESTINE	HSPH1 →	-1.092	-3.764	<.001	<.001	3	2
LARGE_INTESTINE	DCK →	+0.544	+2.043	.002	.008	3	2
LARGE_INTESTINE	NBL1 →	+1.077	+2.043	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,040 associations by consensus.

WDR87 by ADAMTS3 expression — LARGE_INTESTINE

Explore this box plot interactively →