ADAMTS20

Across TCGA patient cohorts, ADAMTS20 mutation is significantly associated with the RNA expression of many other genes, with 5,682 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS20-associated genes across cancer lineages are SPAG5, HJURP, and KIF11. Each is linked with ADAMTS20 in more than 5 cancer types. Because this analysis shows association rather than direction, both ADAMTS20-to-partner and partner-to-ADAMTS20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPAG5 grouped by ADAMTS20-low versus ADAMTS20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS20→partner) and Y-score (partner→ADAMTS20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPAG5 →	+0.488	+1.621	<.001	<.001	3	6
LUAD	HJURP →	+0.556	+1.999	.007	.009	2	6
LUAD	KIF11 →	+0.537	+2.265	.002	<.001	3	5
UCEC	PSMC3IP →	+0.547	+1.351	<.001	<.001	3	5
UCEC	PPM1G →	+0.260	+1.884	.001	<.001	3	5
UCEC	CDCA5 →	+0.474	+1.947	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,682 associations by consensus.

SPAG5 by ADAMTS20 expression — UCEC

Explore this box plot interactively →