ADAMTS20

Across TCGA patient cohorts, ADAMTS20 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS20-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and CD49b. Each is linked with ADAMTS20 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAMTS20-to-partner and partner-to-ADAMTS20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ADAMTS20-low versus ADAMTS20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS20→partner) and Y-score (partner→ADAMTS20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.574	+2.169	<.001	.002	3	5
COAD	Caspase-7-cleavedD198 →	+0.948	+3.584	.001	.002	3	4
BRCA	CD49b →	+0.378	+2.814	.003	.037	3	3
LUAD	cIAP →	+0.078	+2.321	.028	<.001	3	3
STAD	FASN →	+0.427	+2.823	.029	.034	3	3
STAD	PCNA →	+0.451	+3.321	<.001	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Cyclin-B1 by ADAMTS20 expression — UCEC

Explore this box plot interactively →