ADAMTS2

Across TCGA patient cohorts, ADAMTS2 mutation is significantly associated with the RNA expression of many other genes, with 4,758 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS2-associated genes across cancer lineages are THOC2, CCDC112, and KRT18P8. Each is linked with ADAMTS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTS2-to-partner and partner-to-ADAMTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THOC2 grouped by ADAMTS2-low versus ADAMTS2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS2→partner) and Y-score (partner→ADAMTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	THOC2 →	+0.370	+2.052	.002	.004	3	4
COAD	CCDC112 →	+0.392	+2.362	.003	.002	3	4
STAD	KRT18P8 →	+0.511	+3.700	.001	.001	3	4
UCEC	MRPS15 →	+0.295	+2.112	.001	<.001	3	4
UCEC	MND1 →	+0.516	+1.979	.001	.002	3	4
UCEC	RNA5SP412 →	+0.389	+1.623	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,758 associations by consensus.

THOC2 by ADAMTS2 expression — LUAD

Explore this box plot interactively →