ADAMTS2

Across TCGA pan-cancer cohorts, ADAMTS2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ADAMTS2 data layer compared with 9 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ADAMTS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADAMTS2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UVM, MESO, and KIRP are the cancer types where ADAMTS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.426	0.754	<.001	115	view →
MESO	OS	Quartile	II,III,IV	0.221	0.505	.003	101	view →
KIRP	OS	Tertile	All	0.886	0.992	<.001	38	view →
ACC	DFS	Median	All	0.271	0.774	.004	36	view →
UCEC	OS	Tertile	III,IV	0.741	0.349	.002	34	view →
BLCA	OS	Quartile	All	0.567	0.728	.018	28	view →
LUAD	DFS	Tertile	III,IV	0.790	0.256	.003	26	view →
LUSC	DFS	Quartile	III,IV	0.152	0.857	.002	22	view →
HNSC	DFS	Tertile	IV	0.619	0.496	.021	21	view →
STAD	OS	Median	All	0.428	0.654	.012	14	view →
CESC	DFS	Tertile	All	0.778	0.878	.011	12	view →
UCS	OS	Median	IV	0.752	0.404	.013	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ADAMTS2–UVM (OS)

Open the UVM breakdown →