ADAMTS2

Across TCGA patient cohorts, ADAMTS2 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS2-associated genes across cancer lineages are p62 Lck ligand, AR, and JNK2. Each is linked with ADAMTS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTS2-to-partner and partner-to-ADAMTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ADAMTS2-low versus ADAMTS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS2→partner) and Y-score (partner→ADAMTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.423	+1.947	<.001	<.001	3	4
SKCM	AR →	+0.128	+1.662	.018	.011	3	3
UCEC	JNK2 →	+0.159	+1.611	.009	.039	3	3
LUAD	14-3-3_beta →	-0.120	-3.169	.017	.018	3	2
LUAD	ETS-1 →	-0.138	-2.584	.008	.009	3	2
LUAD	XBP1 →	-0.141	-2.305	.027	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

p62 Lck ligand by ADAMTS2 expression — UCEC

Explore this box plot interactively →