ADAMTS2

Across TCGA cell cohorts, ADAMTS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,328 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ADAMTS2-associated GO terms across cancer lineages are Collagen metabolic process, Negative regulation of endodermal cell differentiation, and Keratinocyte development. Each is linked with ADAMTS2 in more than 8 cancer types. Because this analysis shows association rather than direction, both ADAMTS2-to-partner and partner-to-ADAMTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Collagen metabolic process grouped by ADAMTS2-low versus ADAMTS2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS2→partner) and Y-score (partner→ADAMTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Collagen metabolic process →	+0.209	+2.895	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of endodermal cell differentiation →	+0.799	+1.434	.002	.001	3	9
LUNG_NSCLC_LUAD	Keratinocyte development →	+0.151	+0.452	.009	.007	3	9
LIVER	Collagen biosynthetic process →	+0.251	+2.814	<.001	.001	3	8
BONE	Tooth mineralization →	+0.379	+4.051	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Regulation of establishment of blood-brain barrier →	+1.050	+1.766	.002	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,328 associations by consensus.

Collagen metabolic process by ADAMTS2 expression — BONE

Explore this box plot interactively →