ADAMTS2

Across TCGA cell cohorts, ADAMTS2 mutation is significantly associated with the RNA expression of many other genes, with 819 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS2-associated genes across cancer lineages are GABRG1, RIT2, and HELT. Each is linked with ADAMTS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS2-to-partner and partner-to-ADAMTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRG1 grouped by ADAMTS2-low versus ADAMTS2-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS2→partner) and Y-score (partner→ADAMTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GABRG1 →	+0.042	+4.954	<.001	<.001	3	2
URINARY_TRACT	RIT2 →	+0.016	+3.459	<.001	.002	3	2
URINARY_TRACT	HELT →	+0.024	+3.459	<.001	.002	3	2
BLOOD_Lymphoma	PTPRT →	+0.708	+2.497	.008	.007	3	2
LUNG_NSCLC_LUAD	GPR63 →	+0.468	+3.226	.005	.004	3	2
LARGE_INTESTINE	L3MBTL2 →	+0.578	+2.743	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 819 associations by consensus.

GABRG1 by ADAMTS2 expression — KIDNEY

Explore this box plot interactively →