ADAMTS19

Across TCGA patient cohorts, ADAMTS19 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS19-associated genes across cancer lineages are Chk1_pS345, Chk2_pT68, and ASNS. Each is linked with ADAMTS19 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMTS19-to-partner and partner-to-ADAMTS19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1_pS345 grouped by ADAMTS19-low versus ADAMTS19-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS19→partner) and Y-score (partner→ADAMTS19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Chk1_pS345 →	+0.103	+2.000	.005	.031	3	3
LUAD	Chk2_pT68 →	+0.142	+3.169	.029	.018	3	3
UCEC	ASNS →	+0.282	+1.584	.009	.032	3	3
UCEC	Cyclin-B1 →	+0.363	+1.584	.030	.002	3	3
LUAD	14-3-3_beta →	-0.120	-2.683	.037	.006	3	2
LUAD	JNK_pT183_Y185 →	-0.141	-3.321	.026	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Chk1_pS345 by ADAMTS19 expression — LUAD

Explore this box plot interactively →