ADAMTS17

Across TCGA patient cohorts, ADAMTS17 mutation is significantly associated with the RNA expression of many other genes, with 4,047 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS17-associated genes across cancer lineages are DDAH1, SLBP, and CHCHD1. Each is linked with ADAMTS17 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTS17-to-partner and partner-to-ADAMTS17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDAH1 grouped by ADAMTS17-low versus ADAMTS17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS17→partner) and Y-score (partner→ADAMTS17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDAH1 →	+0.567	+1.895	<.001	.001	3	4
UCEC	SLBP →	+0.639	+2.098	<.001	<.001	3	4
UCEC	CHCHD1 →	+0.301	+2.110	<.001	<.001	3	4
UCEC	BCCIP →	+0.455	+1.885	<.001	<.001	3	4
UCEC	GRPEL1 →	+0.494	+2.584	<.001	<.001	3	4
UCEC	CLN6 →	+0.300	+2.222	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,047 associations by consensus.

DDAH1 by ADAMTS17 expression — UCEC

Explore this box plot interactively →