ADAMTS17

Across TCGA pan-cancer cohorts, ADAMTS17 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ADAMTS17’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ADAMTS17 RNA is repressed in tumor relative to normal tissue. In most cancer types ADAMTS17 is over-expressed in tumor, although a few such as KIRP and LUAD show the opposite, repressed pattern.

KIRP, LUAD, and THCA are the cancer types where ADAMTS17 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAMTS17 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	−0.776	<.001	8	view →
LUAD	All	III,IV	−0.608	<.001	8	view →
THCA	All	IV	+0.635	.002	7	view →
BRCA	Female	II,III,IV	+0.331	<.001	6	view →
LUSC	All	All	+0.626	<.001	5	view →
CHOL	All	All	−0.927	.001	4	view →
STAD	All	IV	+0.993	.018	2	view →
BLCA	Male	IV	−0.792	.005	2	view →
KIRC	All	All	−0.178	.003	2	view →
LIHC	All	All	+0.480	.020	1	view →
HNSC	All	All	+0.310	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ADAMTS17–KIRP

Open the KIRP breakdown →