ADAMTS17

Across TCGA cell cohorts, ADAMTS17 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,950 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAMTS17-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Ribonucleoside triphosphate biosynthetic process, and Positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Each is linked with ADAMTS17 in more than 7 cancer types. Because this analysis shows association rather than direction, both ADAMTS17-to-partner and partner-to-ADAMTS17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by ADAMTS17-low versus ADAMTS17-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS17→partner) and Y-score (partner→ADAMTS17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.092	+0.565	<.001	.004	3	8
OESOPHAGUS	Ribonucleoside triphosphate biosynthetic process →	+0.106	+0.907	.007	.008	2	8
BLOOD_Lymphoma	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.057	+1.129	<.001	<.001	3	7
SOFT_TISSUE	Regulation of DNA repair →	+0.067	+0.578	<.001	.001	3	7
BLOOD_Leukemia	Protein depalmitoylation →	+0.094	+1.508	.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Proton motive force-driven mitochondrial ATP synthesis →	+0.121	+0.673	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,950 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by ADAMTS17 expression — UPPER_AERODIGESTIVE_TRACT

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