ADAMTS17

Across TCGA cell cohorts, ADAMTS17 mutation is significantly associated with the RNA expression of many other genes, with 216 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS17-associated genes across cancer lineages are C1orf189, PNLDC1, and RESP18. Each is linked with ADAMTS17 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS17-to-partner and partner-to-ADAMTS17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf189 grouped by ADAMTS17-low versus ADAMTS17-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS17→partner) and Y-score (partner→ADAMTS17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C1orf189 →	+0.191	+3.789	<.001	.004	3	2
LARGE_INTESTINE	PNLDC1 →	+0.071	+3.693	<.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	RESP18 →	+0.040	+5.357	<.001	.003	3	2
SOFT_TISSUE	OR4N4 →	+0.061	+4.930	<.001	.008	3	1
SOFT_TISSUE	KCNK18 →	+0.076	+5.977	<.001	.001	3	1
LUNG_NSCLC_LUAD	GTSF1L →	+0.021	+2.637	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 216 associations by consensus.

C1orf189 by ADAMTS17 expression — BLOOD_Lymphoma

Explore this box plot interactively →