ADAMTS16

Across TCGA patient cohorts, ADAMTS16 mutation is significantly associated with the RNA expression of many other genes, with 6,176 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS16-associated genes across cancer lineages are FBXO5, MAP2K1, and FAM210A. Each is linked with ADAMTS16 in more than 5 cancer types. Because this analysis shows association rather than direction, both ADAMTS16-to-partner and partner-to-ADAMTS16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO5 grouped by ADAMTS16-low versus ADAMTS16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS16→partner) and Y-score (partner→ADAMTS16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXO5 →	+0.411	+1.187	.002	.002	3	6
UCEC	MAP2K1 →	+0.445	+1.447	<.001	<.001	3	5
STAD	FAM210A →	+0.403	+2.940	.003	<.001	3	5
UCEC	HACD3 →	+0.459	+1.648	<.001	<.001	3	5
STAD	SLC17A5 →	+0.694	+2.923	<.001	<.001	3	5
STAD	HSDL1 →	+0.402	+3.492	.008	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,176 associations by consensus.

FBXO5 by ADAMTS16 expression — UCEC

Explore this box plot interactively →