ADAMTS16

Across TCGA pan-cancer cohorts, ADAMTS16 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ADAMTS16 data layer compared with 8 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher ADAMTS16 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADAMTS16 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

STAD, MESO, and LUSC are the cancer types where ADAMTS16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.474	0.657	.001	82	view →
MESO	OS	Median	III,IV	0.312	0.516	.005	81	view →
LUSC	DFS	Quartile	All	0.263	0.516	<.001	59	view →
KIRC	DFS	Quartile	All	0.906	0.813	<.001	58	view →
BLCA	OS	Median	All	0.539	0.685	.001	44	view →
KIRP	OS	Quartile	II,III,IV	0.686	0.259	.004	39	view →
THCA	OS	Quartile	All	0.956	1.000	.002	35	view →
LIHC	DFS	Tertile	II,III,IV	0.300	0.492	.006	27	view →
BRCA	OS	Tertile	IV	0.942	0.232	.002	21	view →
TGCT	DFS	Tertile	All	0.739	0.939	.007	12	view →
SARC	OS	Tertile	All	0.630	0.825	.011	12	view →
SCLC	DFS	Tertile	II,III,IV	0.887	0.253	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ADAMTS16–STAD (OS)

Open the STAD breakdown →