ADAMTS16

Across TCGA cell cohorts, ADAMTS16 mutation is significantly associated with the RNA expression of many other genes, with 421 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS16-associated genes across cancer lineages are FRG2B, XAGE5, and FAM227B. Each is linked with ADAMTS16 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMTS16-to-partner and partner-to-ADAMTS16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRG2B grouped by ADAMTS16-low versus ADAMTS16-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS16→partner) and Y-score (partner→ADAMTS16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FRG2B →	+0.057	+3.736	<.001	.004	3	3
LUNG_SCLC	XAGE5 →	+0.955	+2.199	<.001	.004	3	3
LUNG_NSCLC_LUAD	FAM227B →	+0.521	+2.736	.005	.001	3	3
OESOPHAGUS	MCHR2 →	+0.039	+2.874	<.001	.009	3	2
OVARY	ELSPBP1 →	+0.186	+3.444	<.001	.003	3	2
OVARY	NOTO →	+0.031	+4.000	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 421 associations by consensus.

FRG2B by ADAMTS16 expression — OESOPHAGUS

Explore this box plot interactively →