ADAMTS15

Across TCGA patient cohorts, ADAMTS15 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS15-associated genes across cancer lineages are Cyclin-B1, PCNA, and 4E-BP1_pT37_T46. Each is linked with ADAMTS15 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTS15-to-partner and partner-to-ADAMTS15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ADAMTS15-low versus ADAMTS15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS15→partner) and Y-score (partner→ADAMTS15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.627	+2.584	.002	.010	3	4
UCEC	PCNA →	+0.306	+2.736	<.001	<.001	3	3
UCEC	4E-BP1_pT37_T46 →	-0.359	-1.687	.009	.040	3	3
UCEC	FOXO3a_pS318_S321 →	-0.092	-1.896	.044	.015	3	2
UCEC	JNK2 →	+0.156	+1.884	.033	.030	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.466	-2.234	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Cyclin-B1 by ADAMTS15 expression — UCEC

Explore this box plot interactively →