ADAMTS15

Across TCGA pan-cancer cohorts, ADAMTS15 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ADAMTS15 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ADAMTS15 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADAMTS15 expression acts as an unfavorable survival marker, although some lineages such as ESCA and SCLC show a favorable association.

BLCA, HNSC, and STAD are the cancer types where ADAMTS15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.345	0.506	<.001	100	view →
HNSC	OS	Median	All	0.703	0.798	.001	61	view →
STAD	OS	Median	II,III,IV	0.452	0.653	.002	57	view →
UVM	OS	Tertile	III,IV	0.451	0.931	.003	52	view →
ESCA	DFS	Median	III,IV	0.585	0.277	<.001	45	view →
UCEC	DFS	Quartile	All	0.590	0.772	.001	42	view →
CESC	OS	Tertile	All	0.743	0.891	.002	42	view →
SCLC	DFS	Tertile	II,III,IV	0.737	0.402	.005	38	view →
SKCM	DFS	Median	III,IV	0.410	0.598	<.001	38	view →
SARC	DFS	Quartile	All	0.752	0.503	<.001	34	view →
LAML	DFS	Quartile	All	0.563	0.275	.003	34	view →
LUAD	DFS	Tertile	IV	0.262	0.896	.006	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ADAMTS15–BLCA (OS)

Open the BLCA breakdown →