ADAMTS15

Across TCGA cell cohorts, ADAMTS15 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAMTS15-associated genes across cancer lineages are CLVS2, KRT71, and LCE2B. Each is linked with ADAMTS15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS15-to-partner and partner-to-ADAMTS15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLVS2 grouped by ADAMTS15-low versus ADAMTS15-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS15→partner) and Y-score (partner→ADAMTS15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLVS2 →	+0.327	+3.754	<.001	.008	3	2
PANCREAS	KRT71 →	+0.044	+3.700	<.001	.008	3	1
PANCREAS	LCE2B →	+0.031	+4.139	<.001	.001	3	1
PANCREAS	OR1E1 →	+0.004	+4.029	<.001	.007	3	1
PANCREAS	LCE2A →	+0.020	+4.029	<.001	.007	3	1
PANCREAS	LELP1 →	+0.020	+4.029	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

CLVS2 by ADAMTS15 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →