ADAMTS15

Across TCGA cell cohorts, ADAMTS15 mutation is significantly associated with the mutation status of many other genes, with 4,198 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS15-associated genes across cancer lineages are MED12, PCDHA13, and TACC2. Each is linked with ADAMTS15 in more than 5 cancer types. Because this analysis shows association rather than direction, both ADAMTS15-to-partner and partner-to-ADAMTS15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED12 grouped by ADAMTS15-low versus ADAMTS15-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS15→partner) and Y-score (partner→ADAMTS15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MED12 →	+2.977	+4.273	.006	.006	1	6
BLOOD_Leukemia	PCDHA13 →	+1.847	+1.959	.009	.009	1	6
SOFT_TISSUE	TACC2 →	+5.066	+4.502	.007	.007	1	6
SOFT_TISSUE	UBR4 →	+3.066	+4.369	.005	.005	1	6
STOMACH	PCDHA2 →	+4.807	+4.807	.008	.008	1	6
BLOOD_Lymphoma	ZNF618 →	+4.108	+3.510	.003	.003	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,198 associations by consensus.

MED12 by ADAMTS15 expression — OVARY

Explore this box plot interactively →