ADAMTS12

Across TCGA cell cohorts, ADAMTS12 mutation is significantly associated with the RNA expression of many other genes, with 485 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS12-associated genes across cancer lineages are PPM1M, CLNK, and OR2J3. Each is linked with ADAMTS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS12-to-partner and partner-to-ADAMTS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPM1M grouped by ADAMTS12-low versus ADAMTS12-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS12→partner) and Y-score (partner→ADAMTS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PPM1M →	+1.280	+3.000	<.001	.003	3	2
OESOPHAGUS	CLNK →	+0.021	+3.722	.002	.001	3	2
OESOPHAGUS	OR2J3 →	+0.037	+2.906	<.001	.004	3	2
BREAST	NDN →	+1.472	+3.169	.001	.009	3	2
LUNG_SCLC	AUNIP →	+0.554	+3.169	.003	.006	3	2
LUNG_SCLC	TMEM268 →	+0.594	+3.169	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 485 associations by consensus.

PPM1M by ADAMTS12 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →