ADAMTS10

Across TCGA patient cohorts, ADAMTS10 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS10-associated genes across cancer lineages are Rictor_pT1135, Src_pY527, and Bad_pS112. Each is linked with ADAMTS10 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMTS10-to-partner and partner-to-ADAMTS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by ADAMTS10-low versus ADAMTS10-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS10→partner) and Y-score (partner→ADAMTS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Rictor_pT1135 →	-0.153	-3.443	.008	.004	3	2
STAD	Src_pY527 →	-0.659	-3.321	<.001	.009	3	2
STAD	Bad_pS112 →	-0.205	-2.201	.010	.010	3	2
STAD	c-Jun_pS73 →	-0.180	-3.169	.010	.017	3	2
UCEC	MEK1 →	+0.332	+2.321	.002	<.001	3	2
COAD	XBP1 →	+0.260	+2.815	.012	.036	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Rictor_pT1135 by ADAMTS10 expression — STAD

Explore this box plot interactively →