ADAMTS10

Across TCGA cell cohorts, ADAMTS10 mutation is significantly associated with the RNA expression of many other genes, with 1,625 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS10-associated genes across cancer lineages are LCE1C, KLC3, and SEPTIN3. Each is linked with ADAMTS10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS10-to-partner and partner-to-ADAMTS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1C grouped by ADAMTS10-low versus ADAMTS10-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS10→partner) and Y-score (partner→ADAMTS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LCE1C →	+0.051	+5.472	<.001	<.001	3	2
BLOOD_Leukemia	KLC3 →	+0.317	+3.285	<.001	.008	3	2
LARGE_INTESTINE	SEPTIN3 →	+1.155	+2.351	<.001	.001	3	2
LARGE_INTESTINE	PPP4R3A →	+0.432	+2.351	.001	.001	3	2
LARGE_INTESTINE	BRMS1L →	+0.465	+2.265	.005	.001	3	2
LARGE_INTESTINE	CEP76 →	+0.656	+2.265	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,625 associations by consensus.

LCE1C by ADAMTS10 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →