ADAMTS1

Across TCGA patient cohorts, ADAMTS1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS1-associated genes across cancer lineages are eIF4E, MEK1, and Caspase-7-cleavedD198. Each is linked with ADAMTS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS1-to-partner and partner-to-ADAMTS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ADAMTS1-low versus ADAMTS1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS1→partner) and Y-score (partner→ADAMTS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.191	+2.820	.023	.035	3	2
UCEC	MEK1 →	+0.348	+1.652	.003	.006	3	2
COAD	Caspase-7-cleavedD198 →	+1.531	+3.330	<.001	.005	3	2
COAD	4E-BP1 →	+0.292	+2.178	.004	.035	3	2
UCEC	eEF2 →	+0.276	+2.584	.019	.010	3	2
UCEC	FoxM1 →	+0.249	+2.263	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eIF4E by ADAMTS1 expression — COAD

Explore this box plot interactively →