ADAMTS1

Across TCGA pan-cancer cohorts, ADAMTS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ADAMTS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ADAMTS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ADAMTS1 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and LUAD are the cancer types where ADAMTS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAMTS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−3.549	<.001	11	view →
COAD	Female	II,III,IV	−1.376	<.001	11	view →
LUAD	Male	All	−1.996	<.001	9	view →
KICH	All	II,III,IV	−2.852	<.001	8	view →
UCEC	All	II,III,IV	−2.568	<.001	8	view →
BRCA	All	III,IV	−2.427	<.001	6	view →
LUSC	Male	II,III,IV	−1.852	<.001	5	view →
STAD	Female	All	−2.017	.006	4	view →
READ	Female	All	−1.742	.013	2	view →
LIHC	Male	All	−0.962	<.001	2	view →
THCA	All	All	−0.536	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ADAMTS1–BLCA

Open the BLCA breakdown →