ADAMTS1

Across TCGA cell cohorts, ADAMTS1 mutation is significantly associated with the RNA expression of many other genes, with 802 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS1-associated genes across cancer lineages are CEACAM20, SLCO1C1, and DSG1. Each is linked with ADAMTS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS1-to-partner and partner-to-ADAMTS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM20 grouped by ADAMTS1-low versus ADAMTS1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS1→partner) and Y-score (partner→ADAMTS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CEACAM20 →	+0.153	+4.247	<.001	<.001	3	2
BLOOD_Lymphoma	SLCO1C1 →	+0.029	+4.169	<.001	.002	3	2
BLOOD_Leukemia	DSG1 →	+0.166	+3.584	<.001	.004	3	2
BLOOD_Leukemia	IGSF1 →	+1.070	+3.540	<.001	.005	3	2
BLOOD_Leukemia	XCR1 →	+0.032	+3.415	.001	.004	3	2
BLOOD_Leukemia	TRIM60 →	+0.018	+3.786	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 802 associations by consensus.

CEACAM20 by ADAMTS1 expression — SOFT_TISSUE

Explore this box plot interactively →