ADAMDEC1

Across TCGA patient cohorts, ADAMDEC1 mutation is significantly associated with the RNA expression of many other genes, with 2,900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMDEC1-associated genes across cancer lineages are EZH2P1, MRPL35P1, and CBX3P8. Each is linked with ADAMDEC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMDEC1-to-partner and partner-to-ADAMDEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EZH2P1 grouped by ADAMDEC1-low versus ADAMDEC1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMDEC1→partner) and Y-score (partner→ADAMDEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EZH2P1 →	+0.145	+4.107	<.001	.001	3	3
LIHC	MRPL35P1 →	+0.086	+6.008	<.001	.002	3	2
PRAD	CBX3P8 →	+0.079	+7.939	<.001	.008	3	2
BLCA	CYP3A54P →	+0.342	+7.640	<.001	.009	3	2
BLCA	MRPS5P4 →	+0.094	+7.640	<.001	.009	3	2
BRCA	CHEK2P3 →	+0.136	+4.505	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,900 associations by consensus.

EZH2P1 by ADAMDEC1 expression — BRCA

Explore this box plot interactively →