ADAMDEC1

Across TCGA patient cohorts, ADAMDEC1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMDEC1-associated genes across cancer lineages are FoxM1, MEK1, and Annexin_VII. Each is linked with ADAMDEC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMDEC1-to-partner and partner-to-ADAMDEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ADAMDEC1-low versus ADAMDEC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMDEC1→partner) and Y-score (partner→ADAMDEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.293	+3.169	.006	.018	3	2
UCEC	MEK1 →	+0.499	+3.000	<.001	.001	3	2
UCEC	Annexin_VII →	-0.143	-2.321	.012	.006	3	2
UCEC	Di-Ras3 →	-0.182	-2.571	.002	.010	3	2
UCEC	eIF4E →	+0.194	+2.321	.026	.006	3	1
UCEC	FASN →	+0.498	+3.169	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

FoxM1 by ADAMDEC1 expression — UCEC

Explore this box plot interactively →