ADAM7

Across TCGA patient cohorts, ADAM7 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM7-associated genes across cancer lineages are ASNS, ATM, and TSC1. Each is linked with ADAM7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM7-to-partner and partner-to-ADAM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ADAM7-low versus ADAM7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM7→partner) and Y-score (partner→ADAM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.338	+2.415	.001	.002	3	3
UCEC	ATM →	-0.560	-2.099	<.001	<.001	3	3
COAD	TSC1 →	-0.371	-2.213	<.001	.010	3	3
COAD	Bid →	+0.099	+3.033	.021	.017	3	3
COAD	beta-Catenin →	-0.676	-2.213	.007	.010	3	2
LUSC	Dvl3 →	+0.254	+3.179	.008	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

ASNS by ADAM7 expression — UCEC

Explore this box plot interactively →