Across TCGA patient cohorts, ADAM5 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM5-associated genes across cancer lineages are RPL23AP88, IGHV4-4, and PMS2P6. Each is linked with ADAM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM5-to-partner and partner-to-ADAM5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM5→partner) and Y-score (partner→ADAM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP88 →	+0.327	+4.169	<.001	.002	3	1
UCEC	IGHV4-4 →	+2.327	+3.690	<.001	.007	3	1
UCEC	PMS2P6 →	+0.471	+3.818	<.001	.005	3	1
UCEC	PPIAL4C →	+0.194	+3.917	.002	.004	3	1
UCEC	SNORD3A →	+0.553	+3.942	<.001	.004	3	1
UCEC	MIR4285 →	+0.583	+3.888	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

ADAM5 survival (RNA) · tumor vs normal (RNA) · all ADAM5 data types