ADAM33

Across TCGA cell cohorts, ADAM33 mutation is significantly associated with the RNA expression of many other genes, with 200 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM33-associated genes across cancer lineages are KHDC3L, C12orf40, and SEC22B. Each is linked with ADAM33 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM33-to-partner and partner-to-ADAM33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDC3L grouped by ADAM33-low versus ADAM33-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM33→partner) and Y-score (partner→ADAM33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KHDC3L →	+0.191	+3.359	<.001	.001	3	2
LARGE_INTESTINE	C12orf40 →	+0.005	+2.514	.007	.007	3	2
LARGE_INTESTINE	SEC22B →	+0.464	+3.212	.007	.006	3	2
SKIN	OR1E3 →	+0.036	+6.022	<.001	.001	3	1
CNS	KRTAP11-1 →	+0.017	+4.754	<.001	.005	3	1
CNS	ARMH2 →	+0.111	+4.643	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 200 associations by consensus.

KHDC3L by ADAM33 expression — BLOOD_Leukemia

Explore this box plot interactively →