ADAM30

Across TCGA patient cohorts, ADAM30 mutation is significantly associated with the RNA expression of many other genes, with 3,173 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM30-associated genes across cancer lineages are GJE1, IPPKP1, and LIN7C. Each is linked with ADAM30 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM30-to-partner and partner-to-ADAM30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJE1 grouped by ADAM30-low versus ADAM30-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM30→partner) and Y-score (partner→ADAM30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	GJE1 →	+0.063	+5.807	<.001	.003	3	2
PRAD	IPPKP1 →	+0.063	+5.897	<.001	.002	3	2
UCEC	LIN7C →	+0.475	+2.510	.003	.001	3	2
UCEC	AP1S3 →	+0.757	+3.169	<.001	<.001	3	2
SKCM	GPATCH11 →	+0.543	+2.434	.002	.001	3	2
UCEC	TMEM251 →	+0.432	+1.923	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,173 associations by consensus.

GJE1 by ADAM30 expression — PRAD

Explore this box plot interactively →