ADAM30

Across TCGA patient cohorts, ADAM30 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM30-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and MYH11. Each is linked with ADAM30 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM30-to-partner and partner-to-ADAM30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ADAM30-low versus ADAM30-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM30→partner) and Y-score (partner→ADAM30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.668	+2.459	.002	.018	3	3
SKCM	eIF4E →	+0.156	+2.000	.024	.009	3	2
SKCM	MYH11 →	-0.713	-1.584	.034	.035	3	2
SKCM	Caspase-8 →	-0.238	-2.502	<.001	.001	3	2
SKCM	c-Met →	-0.146	-1.567	.010	.035	3	2
UCEC	Notch1 →	+0.120	+2.013	.020	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Caspase-7-cleavedD198 by ADAM30 expression — UCEC

Explore this box plot interactively →