ADAM30

Across TCGA cell cohorts, ADAM30 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAM30-associated genes across cancer lineages are DSG4, MBL2, and PRR30. Each is linked with ADAM30 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM30-to-partner and partner-to-ADAM30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSG4 grouped by ADAM30-low versus ADAM30-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM30→partner) and Y-score (partner→ADAM30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DSG4 →	+0.017	+3.000	<.001	.006	3	2
CNS	MBL2 →	+0.174	+2.906	<.001	.009	3	1
CNS	PRR30 →	+0.009	+3.473	.002	.001	3	1
CNS	GSC2 →	+0.040	+3.523	.008	.001	3	1
BLOOD_Lymphoma	NEUROD6 →	+0.006	+5.643	.003	.002	3	1
BLOOD_Lymphoma	CCL11 →	+0.028	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

DSG4 by ADAM30 expression — CNS

Explore this box plot interactively →