ADAM23

Across TCGA pan-cancer cohorts, ADAM23 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ADAM23 data layer compared with 8 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ADAM23 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADAM23 expression acts as an unfavorable survival marker, although some lineages such as LUSC and UCS show a favorable association.

KIRP, BLCA, and UVM are the cancer types where ADAM23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.796	0.967	<.001	107	view →
BLCA	DFS	Quartile	All	0.247	0.507	<.001	99	view →
UVM	DFS	Tertile	II,III,IV	0.409	0.950	<.001	92	view →
LUSC	DFS	Tertile	All	0.809	0.686	.001	42	view →
UCS	DFS	Median	II,III,IV	0.528	0.159	.008	30	view →
HNSC	DFS	Quartile	All	0.772	0.597	.005	26	view →
THCA	OS	Tertile	II,III,IV	0.749	1.000	.008	25	view →
ESCA	OS	Quartile	All	0.764	0.543	.010	24	view →
LGG	OS	Tertile	All	0.806	0.978	<.001	13	view →
THYM	DFS	Quartile	All	0.576	0.945	.025	13	view →
TGCT	DFS	Quartile	All	0.971	0.672	.001	12	view →
SKCM	OS	Tertile	IV	0.527	0.840	.030	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ADAM23–KIRP (DFS)

Open the KIRP breakdown →