ADAM23

Across TCGA pan-cancer cohorts, ADAM23 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ADAM23’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADAM23 RNA is repressed in tumor relative to normal tissue. In most cancer types ADAM23 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where ADAM23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAM23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	−0.804	<.001	12	view →
HNSC	Male	III,IV	+2.051	<.001	11	view →
KICH	Female	II,III,IV	−1.081	<.001	11	view →
THCA	Female	II,III,IV	−0.565	<.001	6	view →
LUSC	Male	All	+2.278	<.001	5	view →
LIHC	All	All	+0.619	<.001	5	view →
COAD	All	II,III,IV	−0.406	.001	5	view →
BRCA	All	All	−0.209	.006	4	view →
CHOL	All	All	+1.003	.019	3	view →
READ	Female	All	−1.097	.002	2	view →
PRAD	All	All	−0.284	.008	2	view →
KIRP	Male	All	−0.655	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ADAM23–KIRC

Open the KIRC breakdown →