ADAM21

Across TCGA patient cohorts, ADAM21 protein abundance is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ADAM21-associated genes across cancer lineages are MAB21L2, DEFB108B, and CROCCP5. Each is linked with ADAM21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM21-to-partner and partner-to-ADAM21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAM21 versus MAB21L2 in BRCA, with a Pearson correlation of 0.92.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM21→partner) and Y-score (partner→ADAM21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAB21L2 →	+0.130	+0.690	.005	.006	2	1
BRCA	DEFB108B →	+0.200	+0.690	.009	.006	2	1
BRCA	CROCCP5 →	+0.164	+0.690	.008	.006	2	1
BRCA	RNASE9 →	+0.055	+0.690	.008	.006	2	1
BRCA	MIR26A1 →	+1.180	+0.690	.004	.006	2	1
BRCA	RNU6-1123P →	+0.940	+0.690	.005	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

ADAM21 vs MAB21L2 — BRCA

Explore this scatter interactively →