ADAM21

Across TCGA patient cohorts, ADAM21 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM21-associated genes across cancer lineages are Smad4, Akt_pS473, and p53. Each is linked with ADAM21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM21-to-partner and partner-to-ADAM21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by ADAM21-low versus ADAM21-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM21→partner) and Y-score (partner→ADAM21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smad4 →	+0.115	+2.841	.013	.033	3	2
UCEC	Akt_pS473 →	+0.515	+2.000	.041	.030	3	2
UCEC	p53 →	-0.289	-2.000	.034	.030	3	2
UCEC	p62 Lck ligand →	+0.350	+2.584	.002	.010	3	2
UCEC	Annexin-1 →	+0.482	+2.019	.009	.017	3	2
UCEC	ASNS →	+0.315	+1.662	.013	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Smad4 by ADAM21 expression — SKCM

Explore this box plot interactively →