ADAM21

Across TCGA cell cohorts, ADAM21 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,554 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAM21-associated GO terms across cancer lineages are Endoplasmic reticulum to Golgi vesicle-mediated transport, Cytoplasmic translation, and Cilium movement. Each is linked with ADAM21 in more than 9 cancer types. Because this analysis shows association rather than direction, both ADAM21-to-partner and partner-to-ADAM21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to Golgi vesicle-mediated transport grouped by ADAM21-low versus ADAM21-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM21→partner) and Y-score (partner→ADAM21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.046	+0.350	.001	<.001	3	9
PANCREAS	Cytoplasmic translation →	+0.076	+0.296	<.001	.001	2	10
UPPER_AERODIGESTIVE_TRACT	Cilium movement →	-0.079	-0.218	.001	.001	3	8
CNS	Regulation of ATP-dependent activity →	+0.089	+0.479	<.001	<.001	3	8
CNS	Positive regulation of cytoplasmic translation →	+0.067	+0.239	<.001	.006	3	8
UPPER_AERODIGESTIVE_TRACT	Process utilizing autophagic mechanism →	+0.048	+0.161	.002	.009	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,554 associations by consensus.

Endoplasmic reticulum to Golgi vesicle-mediated transport by ADAM21 expression — CNS

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