ADAM20

Across TCGA patient cohorts, ADAM20 protein abundance is significantly associated with the RNA expression of many other genes, with 807 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ADAM20-associated genes across cancer lineages are ERC2-IT1, CCDC134, and TCF20. Each is linked with ADAM20 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM20-to-partner and partner-to-ADAM20 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAM20 versus ERC2-IT1 in GBM, with a Pearson correlation of 0.87.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM20→partner) and Y-score (partner→ADAM20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ERC2-IT1 →	+1.132	+0.685	.002	.003	3	2
CCRCC	CCDC134 →	-0.664	-0.848	.007	.004	3	1
CCRCC	TCF20 →	-0.575	-1.110	.001	.004	3	1
CCRCC	BBC3 →	-0.837	-0.891	<.001	.001	3	1
CCRCC	NAGLU →	-0.796	-0.910	.006	.001	3	1
CCRCC	SOX6 →	-1.535	-1.244	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 807 associations by consensus.

ADAM20 vs ERC2-IT1 — GBM

Explore this scatter interactively →