ADAM20

Across TCGA pan-cancer cohorts, ADAM20 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ADAM20’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ADAM20 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADAM20 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LUSC, THCA, and KICH are the cancer types where ADAM20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAM20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	+0.216	<.001	8	view →
THCA	All	All	−0.065	<.001	6	view →
KICH	Male	III,IV	−0.067	.001	3	view →
UCEC	All	All	−0.082	.007	2	view →
BRCA	All	III,IV	−0.059	.045	2	view →
COAD	All	All	+0.042	.018	2	view →
KIRP	All	IV	+0.037	.040	2	view →
LUAD	Female	II,III,IV	−0.088	.018	1	view →
HNSC	All	II,III,IV	+0.052	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ADAM20–LUSC

Open the LUSC breakdown →