ADAM20

Across TCGA patient cohorts, ADAM20 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM20-associated genes across cancer lineages are ATM, Cyclin-E2, and MEK1. Each is linked with ADAM20 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM20-to-partner and partner-to-ADAM20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ADAM20-low versus ADAM20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM20→partner) and Y-score (partner→ADAM20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.417	-1.700	.010	.042	3	3
UCEC	Cyclin-E2 →	+0.121	+2.009	.046	.017	3	3
UCEC	MEK1 →	+0.317	+2.321	.016	.005	3	2
UCEC	4E-BP1 →	+0.280	+1.904	.004	.029	3	2
UCEC	14-3-3_beta →	-0.081	-1.847	.025	.049	3	1
UCEC	eIF4E →	+0.163	+1.925	.032	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by ADAM20 expression — UCEC

Explore this box plot interactively →