ADAM20

Across TCGA cell cohorts, ADAM20 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,079 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible ADAM20-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Regulation of mRNA splicing, via spliceosome, and mRNA 5'-splice site recognition. Each is linked with ADAM20 in more than 11 cancer types. Because this analysis shows association rather than direction, both ADAM20-to-partner and partner-to-ADAM20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by ADAM20-low versus ADAM20-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM20→partner) and Y-score (partner→ADAM20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of alternative mRNA splicing, via spliceosome →	+0.122	+0.096	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.096	+0.170	<.001	.001	3	12
OESOPHAGUS	mRNA 5'-splice site recognition →	+0.120	+0.128	.005	.008	3	12
PANCREAS	Microtubule nucleation →	+0.100	+0.076	<.001	<.001	3	11
STOMACH	Negative regulation of cilium assembly →	+0.082	+0.107	<.001	<.001	3	11
OESOPHAGUS	Viral transcription →	+0.102	+0.192	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,079 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by ADAM20 expression — STOMACH

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