ADAM20

Across TCGA cell cohorts, ADAM20 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM20-associated genes across cancer lineages are SMR3A, SULT6B1, and DCDC2C. Each is linked with ADAM20 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM20-to-partner and partner-to-ADAM20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMR3A grouped by ADAM20-low versus ADAM20-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM20→partner) and Y-score (partner→ADAM20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SMR3A →	+0.049	+4.736	.001	.009	3	1
LUNG_NSCLC_LUAD	SULT6B1 →	+1.174	+4.662	<.001	.005	3	1
BLOOD_Lymphoma	DCDC2C →	+0.291	+3.954	<.001	.005	3	1
BLOOD_Lymphoma	LINC02881 →	+1.110	+3.736	<.001	.009	3	1
BLOOD_Lymphoma	SPEM3 →	+0.009	+3.954	.003	.005	3	1
LARGE_INTESTINE	GTF2B →	+0.495	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

SMR3A by ADAM20 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →