ADAM18

Across TCGA patient cohorts, ADAM18 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM18-associated genes across cancer lineages are PCNA, PKC-delta_pS664, and 14-3-3_beta. Each is linked with ADAM18 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM18-to-partner and partner-to-ADAM18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ADAM18-low versus ADAM18-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM18→partner) and Y-score (partner→ADAM18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.320	+2.815	.018	.036	3	3
LUSC	PKC-delta_pS664 →	-0.196	-3.169	.001	.018	3	2
UCEC	14-3-3_beta →	-0.091	-2.973	.033	.035	3	2
UCEC	eEF2 →	+0.385	+3.169	.011	.018	3	2
UCEC	EGFR_pY1068 →	-0.306	-3.459	.004	.005	3	2
UCEC	ERK2 →	+0.251	+3.169	.002	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PCNA by ADAM18 expression — COAD

Explore this box plot interactively →