ADAM18

Across TCGA cell cohorts, ADAM18 RNA expression is significantly associated with the go_rna of many other GO terms, with 585 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible ADAM18-associated GO terms across cancer lineages are Sphingolipid catabolic process, Chemokine (C-X-C motif) ligand 12 signaling pathway, and Adult heart development. Each is linked with ADAM18 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAM18-to-partner and partner-to-ADAM18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sphingolipid catabolic process grouped by ADAM18-low versus ADAM18-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM18→partner) and Y-score (partner→ADAM18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Sphingolipid catabolic process →	+0.065	+1.036	.005	.003	3	4
KIDNEY	Chemokine (C-X-C motif) ligand 12 signaling pathway →	-0.131	-1.467	.007	<.001	3	4
LUNG_NSCLC_LUAD	Adult heart development →	-1.232	-0.047	<.001	.009	3	3
SKIN	Positive regulation of amine transport →	-0.123	-0.026	<.001	.006	3	3
KIDNEY	Manganese ion transport →	+0.139	+1.017	<.001	.003	3	3
OVARY	Notch receptor processing →	+0.059	+0.210	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 585 associations by consensus.

Sphingolipid catabolic process by ADAM18 expression — KIDNEY

Explore this box plot interactively →